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Independent evidence before payment.
Anti-inflammatory tripeptide · also: alpha-MSH 11-13 fragment
KPV carries an Evidence Grade of C (Medium confidence). The strongest published evidence catalogued is human (other).
Grade C rule: At least one other human study.
The grade reflects the strength of the published evidence, not safety or efficacy. “Confidence” means how settled that grade is given the record — not how likely the compound is to work.
Human-use stop
This compound is investigational, warned or not approved for human use. A seller calling it “research only,” showing testimonials, registering a company or publishing a COA does not create an approved consumer medicine. Seller links below are market-surveillance records, not recommendations.
KPV is a tripeptide fragment of alpha-MSH studied preclinically for anti-inflammatory signalling, particularly in gut-related in-vitro and animal models.
Animal and in-vitro results are shown separately and must never be read as established human outcomes.
In plain terms: there is 1 human study, but no randomised trial — the strongest test has not been done. Effects seen in smaller studies often do not hold up.
Strongest: randomised or pooled human trials.
none catalogued
Observational, open-label or small human studies.
Antimicrobial effects of alpha-MSH peptides. Journal of leukocyte biology, 2000.
Preclinical animal models — not a human outcome.
Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer. Oncogene, 2023.
Cell / tissue studies — not a human outcome.
alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells. The Journal of investigative dermatology, 2004.
Proposed mechanism — hypothesis, not evidence of effect.
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development. Cell death and differentiation, 2026.
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway. Tissue & cell, 2025.
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis. ACS applied materials & interfaces, 2017.
Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore. Advances in experimental medicine and biology, 2010.
Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide. Experimental eye research, 2006.
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. The Journal of pharmacology and experimental therapeutics, 2003.
New insights into the functions of alpha-MSH and related peptides in the immune system. Annals of the New York Academy of Sciences, 2003.
The neuropeptide alpha-MSH in host defense. Annals of the New York Academy of Sciences, 2000.
The neuroimmunomodulatory peptide alpha-MSH. Annals of the New York Academy of Sciences, 2000.
On “cited by N”: citation counts (Crossref) reflect how often a paper has been referenced — a measure of academic attention, not of validity, safety, or whether a compound works. They do not affect the Evidence Grade, which is set purely by the strength of the evidence tier.
Human evidence is absent to minimal. Anti-inflammatory findings are preclinical and must not be read as human outcomes.
Not an approved medicine in major markets. Sold only as a “research chemical”, with no established safe consumer use, dose or supply standard.
PepCred flags any vendor selling this compound to the public as a consumer-protection concern. Status reflects regulator records; see the regulatory detail below.
No FDA-approved (US) drug labelling found for this compound. A search of openFDA returned no approved product containing it as an active ingredient.
This reflects US FDA approval only — other regulators (e.g. MHRA, EMA) may differ; see the note below. Absence of an approved label is not, by itself, a safety finding, and a “research use only” label does not establish safety, legality or correct identity.
PepCred note: Not approved for human use.
These unranked records show where the name was detected. For an investigational, warned or unapproved compound, no seller, company registration, review score or COA creates an approved human-use route.
None of these is verified for human use.